Tissue Research

KPV

For Research Use Only. Not for Human Consumption.

CAS: 67727-97-3MW: 342.43 DaPurity: ≥98%Also: Lys-Pro-Val, alpha-MSH C-terminal tripeptide

C₁₅H₂₈N₄O₄

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Overview

The three-amino-acid tail of a natural hormone (alpha-MSH), studied in the lab for its effect on inflammatory signaling pathways. Freeze-dried powder, ≥98% pure (HPLC). For research use only.

Mechanism of Action

A tiny three-amino-acid peptide studied for how it influences inflammation-related cell signaling.

Research Applications

Anti-inflammatory pathway research
NF-κB modulation studies
Mucosal tissue models

Research Studies

The tripeptide KPV derived from alpha-MSH inhibits inflammatory cytokine production and intestinal epithelial permeability in vitro^[1]

This in vitro study investigated the anti-inflammatory properties of the alpha-MSH C-terminal tripeptide KPV (Lys-Pro-Val) in human intestinal epithelial cells (Caco-2) stimulated with pro-inflammatory cytokines. KPV at nanomolar to micromolar concentrations reduced secretion of IL-8 and TNF-alpha in a concentration-dependent manner. Transepithelial electrical resistance measurements demonstrated that KPV preserved epithelial barrier integrity following inflammatory challenge. The authors attributed these effects to partial agonism at MC1R and inhibition of NF-kB p65 nuclear translocation, identifying KPV as a minimal bioactive unit of the parent alpha-MSH peptide.

Last verified: 2026-04-03

Oral delivery of nanoparticle-encapsulated KPV reduces intestinal inflammation in an experimental colitis model^[2]

Researchers developed a nanoparticle delivery system for oral KPV and evaluated its efficacy in a DSS-induced murine colitis model. KPV-loaded chitosan nanoparticles were evaluated by gavage and demonstrated significantly improved mucosal delivery compared to free peptide. Research subjects showed reduced histological colitis scores, decreased colon myeloperoxidase activity (a marker of neutrophil infiltration), and lower pro-inflammatory cytokine levels in colonic tissue. The study demonstrated that nanoparticle encapsulation overcomes KPV's short half-life to achieve investigational tissue concentrations via the oral route.

Last verified: 2026-04-03

References

[1]Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2008. 10.1152/ajpgi.00483.2007
[2]Laroui H, Dalmasso G, Nguyen HT, Yan Y, Sitaraman SV, Merlin D. Gastroenterology. 2010. 10.1053/j.gastro.2009.09.006

Storage & Form

Form

Lyophilized Powder

Purity

≥98%

342.43 Da

-20°C, protected from light and moisture

Research Use Only

For Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All NuLumin Bio-Sciences products are designated Research Use Only (RUO). Not intended for therapeutic use or diagnostic purposes. Purchasers assume responsibility for ensuring compliance with all applicable regulations.